Pseudomonas aeruginosa pdf thesis

Pseudomonas aeruginosa iron acquisition in cystic fibrosis thesis, doctor of philosophy. Ruparell, avika 2012 interplay between quorum sensing and metabolism in pseudomonas aeruginosa. Pseudomonas aeruginosa is an organism commonly found in the environment, and one of the most common causes of infectious disease in humans. Pseudomonas aeruginosa is a gramnegative bacillus found widely in nature, in soil and water. Pseudomonas aeruginosa colonization in patients with cystic fibrosis. A thesis submitted in partial fulfillment of the requirements for the. Research described in this dissertation focuses on two important aspects of. Pseudomonas aeruginosa is a gram negative, motile, aerobic rod shaped bacterium which can occur as singles, in pairs and occasionally in short chains. Thesis by liang yang infection microbiology group department of systems biology technical university of denmark july 2009 i. Penjanaan elektrik yang tinggi ini disumbangkan oleh pyocyanin hasilan. Description of bacterial strains used and created in this phd thesis. View pseudomonas aeruginosa research papers on academia. This thesis explores a strategy which aims to counteract p. The work presented in this thesis has found new information regarding the epidemiology of p.

The genus pseudomonas is the major one of the family pseudomonadaceae, which comprises a heterogeneous group of rodshaped, gramnegative, polarly flagellated bacteria. A study of clinical strains of pseudomonas aeruginosa and the investigation of antibiotic resistance mechanisms in the multidrug resistant strain pa a thesis submitted to dublin city university in fulfilment of the requirements for the award of the degree of doctor of philosophy by damien ferguson b. Thermal deactivation of pseudomonas aeruginosa biofilms. Pseudomonas aeruginosa is an opportunistic pathogen that can cause several acute and chronic infections in humans, and it has become an important cause of nosocomial infections and antibiotic resistance. Pseudomonas aeruginosa pathogenicity and antibiotic. Pseudomonas aeruginosa quorumsensing a factor in biofilm development, and an antipathogenic drug target ph. Pseudomonas aeruginosa is an opportunistic pathogen that can cause several acute and chronic infections in humans, and it has become an important cause of. Pseudomonas aeruginosa is a common bacterium, gramnegative opportunistic pathogen capable of infecting humans with compromised natural defenses and causing severe pulmonary disease.

Pdf pathogenic factors of pseudomonas aeruginosa the. Pseudomonas aeruginosa utrecht university repository. Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy. Pdf genotypic characterization of clinical isolates of. Pseudomonas aeruginosa charles river research animal. This is especially true for infections caused by the opportunistic pathogen pseudomonas aeruginosa, with its ability to rapidly develop resistance to multiple classes of antibiotics. Pseudomonas aeruginosa utas eprints university of tasmania. Mechanisms of phenazinemediated extracellular electron. Pseudomonas aeruginosa is a common encapsulated, gramnegative, rodshaped bacterium that can cause disease in plants and animals, including humans. The most common resistance mechanisms are downregulation of the porin oprd, and increased activity of multidrug efflux pumps, primarily mexaboprm. The occurrence of the infection increases with age and can reach 80% in adults behrends et al. Physiology and mechanisms of pyocyanin reduction in.

Extracellular electron transfer eet, the process whereby cells access electron acceptors or donors that reside many cell lengths away, enables metabolic activity by microorganisms, particularly under oxidantlimited conditions that occur in multicellular bacterial biofilms. Pseudomonas aeruginosa a phenomenon of bacterial resistance tanya strateva 1, daniel yordanov 1. Comparison of aspartate transcarbamoylase activity between pseudomonas aeruginosa which has one chromosome and burkholderia cepaciawhich has three chromosomes. Pseudomonas strains are ubiquitous in soil and water and are able to grow in very simple media at the expense of a great variety of organic compounds.

This thesis addresses the possibility that the phenazine pyocyanin acts as an electron acceptor for energy metabolism and exerts beneficial effects on p. Thesis prepared for the degree of master of science. Pseudomonas aeruginosa in tasmania open access repository. Pdf pseudomonas aeruginosa is an opportunistic human pathogen, responsible for frequently. The formation of biofilms by pseudomonas aeruginosa. The distribution of pathogenic pseudomonas aeruginosa in sewage showing 14 of 54 pages in this thesis.

Although different mechanisms underpin this process in individual organisms, a potentially widespread strategy involves. The resistance of pseudomonas aeruginosa to preservatives. A study of clinical strains of pseudomonas aeruginosa and. Evolution of pseudomonas aeruginosa reveals adaptation towards iron acquisition from hemoglobin. Improved confocal imaging and cotreatment with dispersion agents and antibiotics by stacy sommerfeld ross an abstract of a thesis submitted in partial fulfillment of the requirements for the doctor of philosophy degree in pharmacy in the graduate college of the university of iowa may 20. The pseudomonas genome database genome annotation and. Pseudomonas aeruginosa cells were selected for their ability to grow in the presence of 750 ppm alkyldimethylethylbenzyl ammonium chloride qac. Pseudomonas aeruginosa bacterial biofilms by charlotte pye a thesis presented to the university of guelph in partial fulfilment of requirements for the degree of doctor of veterinary science in clinical studies guelph, ontario, canada charlotte pye, august 20.

Ketumpatan kuasa dan ketumpatan arus maksimum yang dijana dalam sfm menggunakan p. Pseudomonas aeruginosa and nosocomial infections free. As a pathogen, it effectively causes disease by acquiring resistance to. Pdf pseudomonas aeruginosa pathogenesis and pathogenic. Evolution and pathoadaptation of pseudomonas aeruginosa. The antibacterial effect of some medicinal plant extracts. Spatial growth patterns of pseudomonas aeruginosa biofilms by ruifang xu a thesis submitted in partial fulfillment of the requirements for the degree of master of science in chemical engineering montana state university bozeman, montana july 2004. Pseudomonas aeruginosa and nosocomial infections bielecki et al. One of the most common pathogens in chronic wounds is pseudomonas aeruginosaa very problematic microbe, due to its ability to formresistant biofilms. Pseudomonas aeruginosa burkholderia cepacia which has. The extract of medicinal plants were prepared using soxhlet apparatus for alcoholic extract, and water reflux for aqueous extracts.

Pseudomonas aeruginosa an overview sciencedirect topics. The opportunistic pathogen pseudomonas aeruginosa excretes redoxactive small molecules called phenazines. People with cystic fibrosis, burn victims, individuals with cancer, and persons infected with hiv are particularly at risk of disease resulting from pseudomonas. Pseudomonas aeruginosa biofilms thesis presented to the graduate council of texas state universitysan marcos in partial fulfillment of the requirements for the degree master of science by lindsey b. The antibacterial activities of extracts were evaluated using the disk. Although the import of resistance mechanisms on mobile genetic elements is always a concern, the most difficult. Multidrug resistant pseudomonas aeruginosa essay examples. Draft genome sequences of pseudomonas aeruginosa b3. Ruparell, avika 2012 interplay between quorum sensing. Pseudomonas aeruginosa zh1 melalui analisa susunan gen 16s rrna. These drug resistant pathogen has proved challenging for many drug manufacturers because of its mechanisms of action. The large genome, which approaches the complexity and size of lower eukaryotes, and an abundance of regulators, facilitates adaptation to almost any environment. Ferrous iron sensing and responding in pseudomonas aeruginosa.

Pseudomonas aeruginosa iron acquisition in cystic fibrosis. Summary treatment of infectious diseases becomes more challenging with each passing year. Pseudomonas aeruginosa heinrichheineuniversitat dusseldorf. Research paper pseudomonas aeruginosa is a gramnegative bacteria, particularly known for causing nosocomial infections 1. Access from the university of nottingham repository. The objective of this report is to provide an overview i on p.

Pseudomonas aeruginosa is one of the most common organisms isolated from the respiratory tract of cystic fibrosis patients bendiak and ratjen 2009. It belongs to the newly characterized natural cp inhibitors of the i42 family, designated the icp family. Carbapenem imipenem and meropenem resistance in pseudomonas aeruginosa is increasing, with global resistance rates approaching 20%. The distribution of pathogenic pseudomonas aeruginosa in. Master of science molecular biology, august 2012pages, 22, 1 table. Thermal deactivation of pseudomonas aeruginosa biofilms by ann marie otoole a thesis submitted in partial fulfillment of the requirements for the master of science degree in chemical and biochemical engineering in the graduate college of the university of iowa may 2015 thesis supervisor. Pseudomonas aeruginosa inhibitor of cysteine peptidases paicp is a potent protein inhibitor of papainlike cysteine peptidases cps identified in pseudomonas aeruginosa, an opportunistic pathogenic bacteria that can cause severe infections in human. Pseudomonas aeruginosa pseudomonas aeruginosa is a versatile gram negative bacterium that grows in soil, marshes, and coastal marine habitats, as well as on plant and animal tissues. Structure and dynamics of pseudomonas aeruginosa icp. The bacteria produce several virulence factors that allows for establishment in host tissue, where one important substance is the blue pigment pyocyanin. Over the years, pseudomonas aeruginosa has served as a paradigm for the study of gene expression, metabolism, and pathogenesis. Polyvalent inhibitors of pseudomonas aeruginosa adhesion franz edward boas advised by prof. Pseudomonas aeruginosa is a ubiquitous extracellular gramnegative bacterium. Multidrug resistant pseudomonas aeruginosa is one of the major problems facing most countries in fighting pneumonia.